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Consistent with our findings with ECIG-flavor-2 in the bronchial model, decreased SCGB1A1, increased SLPI, and increased PI3 levels were detected in the sputum from COPD patients compared to smokers without COPD and/or never smokers 78

As a result, while participants acknowledged smoking is harmful, few reported experiencing personal concern or felt they were more likely to make a quit attempt in the near future